Haplotter - explore the evidence for recent positive selection in the human genome

Results for HapMap Phase II (release 21) are now available


Introduction

Haplotter is a web application that has been developed to display the results of a scan for positive selection in the human genome using the HapMap data. For results from the Human Genome Diversity Panel, see the HGDP Selection Browser.

Haplotter can be used as a resource to examine various population genetic measures in a genomic region. Measures that are currently displayed include iHS (a statistic developed to detect recent positive selection), Fay and Wu's H, Tajima's D and Fst.

Guide to usage

The detailed instruction can be found here

Citation information

  • A map of recent positive selection in the human genome. B.F.Voight, S. Kudaravalli, X.Wen, J.K.Pritchard 2006. PLoS Biology 4(3): e72 [PDF]

    The data underlying these analyses are from the Phase 1 and Phase 2 HapMap Project

  • A haplotype map of the human genome. The International HapMap Consortium. 2005 Nature 437, 1299-1320

    Additional resources

  • iHS data files (phase 2): zipped document, iHS scores and ancestral states by population and chromosome for Hapmap phase 2 data
  • iHS data files (phase 1): zipped document, iHS scores and ancestral states by population and chromosome for Hapmap phase 1 data
  • Ancestral states information (phase 2): Estimates of ancestral states for HapMap Phase 2 SNPs based on alignment to the chimpanzee sequence.(format information)
  • Ancestral states information (phase 1): Estimates of ancestral states for HapMap Phase 1 SNPs based on alignment to the chimpanzee sequence.(format information)


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